ER stress induces the unfolded protein response (UPR), which involves activation of three transmembrane receptors, ATF6 (activating transcription factor 6), PERK (protein kinase RNA-like endoplasmic reticulum kinase) and IRE1α (inositol-requiring enzyme 1α) 3 ( Extended Data figure 1a). They also remained tight-lipped about their relationship.Endoplasmic reticulum (ER) stress is a major contributor to inflammatory diseases, such as Crohn’s disease and type 2 diabetes 1, 2. Later, the two stars spoke to their respective parents and got their approval for their wedding. He proposed marriage to Lavanya on her birthday, which falls on December 15. Going by the reports, Varun Tej decided to take their relationship to the next level. Her presence added fuel to the rumours about their relationship. When Varun Tej's sister and actress Niharika Konidela got married in 2020, Lavanya was one of the few celebrities to attend it. The two eventually started attending parties and were spotted together at events as well. It is only during the shooting of their second film, Antariksham 9000 KMPH, that the news about their relationship surfaced. However, the duo decided to keep their relationship under wraps. Eventually, their friendship blossomed into love and they began dating. ![]() ![]() It is said that the couple became close friends during the film's shooting. Varun Tej met Lavanya Tripathi for the first time on the sets of Mister in 2017.
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